How can you choose which hormonal supplement is right for you? Many estrogen compound advancements have been made since they first came out in the 1970s. The most recent supplement Enjuvia is a longer lasting polymer than the original Premarin. Since it is stronger, it will prevent your getting hot flashes or other side effects of menopause at random times. Have your doctor run tests of your hormonal levels to determine which estrogen compound is right for you.